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Target
Oxysterols receptor LXR-beta
Ligand
BDBM114725
Substrate
n/a
Meas. Tech.
Counterscreen for agonists of the daf-12 abnormal Dauer Formation: Luminescence-based cell-based dose response assay to identify agonists of the Liver-X-Receptor (LXR).
EC50
67491±n/a nM
Citation
 PubChem, PC Counterscreen for agonists of the daf-12 abnormal Dauer Formation: Luminescence-based cell-based dose response assay to identify agonists of the Liver-X-Receptor (LXR). PubChem Bioassay (2013)[AID]
Target
Name:
Oxysterols receptor LXR-beta
Synonyms:
LXRB | Liver X receptor beta (NR1H2) | Liver X, LXR beta | NER | NR1H2 | NR1H2_HUMAN | Nuclear receptor NER | UNR | Ubiquitously-expressed nuclear receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
50978.79
Organism:
Homo sapiens (Human)
Description:
P55055
Residue:
460
Sequence:
MSSPTTSSLDTPLPGNGPPQPGAPSSSPTVKEEGPEPWPGGPDPDVPGTDEASSACSTDWVIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQESQSQSQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
  
Inhibitor
Name:
BDBM114725
Synonyms:
1H-indene-1,2,3-trione 2-[(2-chlorophenyl)hydrazone] | 2-[(2-chlorophenyl)hydrazinylidene]indene-1,3-dione | 2-[(2-chlorophenyl)hydrazono]indane-1,3-quinone | MLS000532731 | SMR000140169 | cid_867445
Type:
Small organic molecule
Emp. Form.:
C15H9ClN2O2
Mol. Mass.:
284.697
SMILES:
Clc1ccccc1NN=c1c(=O)c2ccccc2c1=O |(11.95,-3.35,;12.72,-2.02,;14.26,-2.02,;15.03,-.68,;14.26,.65,;12.72,.65,;11.95,-.68,;10.41,-.68,;9.64,.65,;8.1,.65,;7.2,1.89,;7.68,3.35,;5.75,1.42,;4.41,2.19,;3.08,1.42,;3.08,-.12,;4.41,-.89,;5.75,-.12,;7.2,-.59,;7.68,-2.05,)|
Structure:
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