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Target
Amine oxidase [flavin-containing] B
Ligand
BDBM113742
Substrate
n/a
Meas. Tech.
MAO-A/B Activity and Inhibition Assay
pH
7.5±n/a
Ki
6.5e+3± 4.6e+3 nM
Comments
extracted
Citation
 Prusevich, P; Kalin, JH; Ming, SA; Basso, M; Givens, J; Li, X; Hu, J; Taylor, MS; Cieniewicz, AM; Hsiao, PY; Huang, R; Roberson, H; Adejola, N; Avery, LB; Casero, RA; Taverna, SD; Qian, J; Tackett, AJ; Ratan, RR; McDonald, OG; Feinberg, AP; Cole, PA A Selective Phenelzine Analogue Inhibitor of Histone Demethylase LSD1. ACS Chem Biol 9:1284-93 (2014) [PubMed]  Article
Target
Name:
Amine oxidase [flavin-containing] B
Synonyms:
AOFB_HUMAN | MAO-B | MAOB | Monoamine oxidase type B | Monoamine oxidase type B (MAO B) | Monoamine oxidase type B (MAO B) | Monoamine oxidase type B (MAOB)
Type:
Protein
Mol. Mass.:
58768.76
Organism:
Homo sapiens (Human)
Description:
P27338
Residue:
520
Sequence:
MSNKCDVVVVGGGISGMAAAKLLHDSGLNVVVLEARDRVGGRTYTLRNQKVKYVDLGGSYVGPTQNRILRLAKELGLETYKVNEVERLIHHVKGKSYPFRGPFPPVWNPITYLDHNNFWRTMDDMGREIPSDAPWKAPLAEEWDNMTMKELLDKLCWTESAKQLATLFVNLCVTAETHEVSALWFLWYVKQCGGTTRIISTTNGGQERKFVGGSGQVSERIMDLLGDRVKLERPVIYIDQTRENVLVETLNHEMYEAKYVISAIPPTLGMKIHFNPPLPMMRNQMITRVPLGSVIKCIVYYKEPFWRKKDYCGTMIIDGEEAPVAYTLDDTKPEGNYAAIMGFILAHKARKLARLTKEERLKKLCELYAKVLGSLEALEPVHYEEKNWCEEQYSGGCYTTYFPPGILTQYGRVLRQPVDRIYFAGTETATHWSGYMEGAVEAGERAAREILHAMGKIPEDEIWQSEPESVDVPAQPITTTFLERHLPSVPGLLRLIGLTTIFSATALGFLAHKRGLLVRV
  
Inhibitor
Name:
BDBM113742
Synonyms:
N-[4-(2-Hydrazinylethyl)phenyl]-4-phenylbutanamide dihydrochloride salt (12d)
Type:
Small organic molecule
Emp. Form.:
C18H23N3O
Mol. Mass.:
297.3947
SMILES:
NNCCc1ccc(NC(=O)CCCc2ccccc2)cc1
Structure:
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