Reaction Details  Report a problem with these data
Target
15-hydroxyprostaglandin dehydrogenase [NAD(+)]
Ligand
BDBM118050
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
7.5±n/a
IC50
50.6±n/a nM
Comments
extracted
Citation
 Cho, H; Wu, Y; Choi, C Thiazolidinedione derivative and use thereof US Patent  US8637558 Publication Date 1/28/2014
Target
Name:
15-hydroxyprostaglandin dehydrogenase [NAD(+)]
Synonyms:
15-PGDH | 15-hydroxyprostaglandin dehydrogenase [NAD+] | HPGD | PGDH1 | PGDH_HUMAN | Prostaglandin dehydrogenase 1 (15-PGDH) | SDR36C1
Type:
Enzyme
Mol. Mass.:
28974.46
Organism:
Homo sapiens (Human)
Description:
P15428
Residue:
266
Sequence:
MHVNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFIQCDVADQQQLRDTFRKVVDHFGRLDILVNNAGVNNEKNWEKTLQINLVSVISGTYLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAANLMNSGVRLNAICPGFVNTAILESIEKEENMGQYIEYKDHIKDMIKYYGILDPPLIANGLITLIEDDALNGAIMKITTSKGIHFQDYDTTPFQAKTQ
  
Inhibitor
Name:
BDBM118050
Synonyms:
US8637558, 78
Type:
Small organic molecule
Emp. Form.:
C19H22ClNO4S
Mol. Mass.:
395.9
SMILES:
COc1cc(C=C2SC(O)=NC2=O)cc(Cl)c1OCCC1CCCCC1 |w:5.4,c:9|
Structure:
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