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Target
Mitogen-activated protein kinase 1
Ligand
BDBM120119
Substrate
n/a
Meas. Tech.
Enzymatic Assay
pH
7.3±n/a
IC50
2.2±n/a nM
Comments
extracted
Citation
 Blake, JF; Chicarelli, MJ; Garrey, RF; Gaudino, J; Grina, J; Moreno, DA; Mohr, PJ; Ren, L; Schwarz, J; Chen, H; Robarge, K; Zhou, A Serine/threonine kinase inhibitors US Patent  US8697715 Publication Date 4/15/2014
Target
Name:
Mitogen-activated protein kinase 1
Synonyms:
ERK2 | ERT1 | Extracellular signal-regulated kinase 2 | Extracellular signal-regulated kinase 2 (ERK-2) | Extracellular signal-regulated kinase 2 (ERK2) | MAP Kinase 2/ERK2 | MAPK 2 | MAPK1 | MK01_HUMAN | Mitogen activated kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK2) | Mitogen-activated protein kinase 2 | PRKM1 | PRKM2 | p42-MAPK
Type:
Ser/Thr Protein Kinase
Mol. Mass.:
41392.76
Organism:
Homo sapiens (Human)
Description:
P28482
Residue:
360
Sequence:
MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
  
Inhibitor
Name:
BDBM120119
Synonyms:
US8697715, 270 | US9259470, 270
Type:
Small organic molecule
Emp. Form.:
C24H19ClFN5O4
Mol. Mass.:
495.89
SMILES:
COC(=O)c1cc(Nc2nccc(n2)-c2ccn([C@H](CO)c3ccc(Cl)c(F)c3)c(=O)c2)ccn1 |r|
Structure:
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