Target
Dihydroorotate dehydrogenase (quinone), mitochondrial [100-517]
Ligand
BDBM120364
Substrate
n/a
Meas. Tech.
Enzymatic Assays
IC50
>10000±n/a nM
Citation
 Bastos, CBooker, MLCelatka, CAClardy, JCCortese, JPatel, VPSkerlj, RWiegand, RCWirth, DF Small molecule inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase US Patent  US8703811 Publication Date 4/22/2014
Target
Name:
Dihydroorotate dehydrogenase (quinone), mitochondrial [100-517]
Synonyms:
Dihydroorotate Dehydrogenase (DHODH) | Dihydroorotate dehydrogenase, mitochondrial, putative
Type:
Enzyme
Mol. Mass.:
47311.25
Organism:
Plasmodium berghei
Description:
A0A509AEH5[100-517]
Residue:
418
Sequence:
MKRFDERMNKEKSKHKKVLFFIFSSIVGLYMYFESYNPEFFMYDVFLDFCLNYVDSEVCHDLFLLLGKYGLLPYDTSNDSVYATSDIKNLNFINPFGVAAGFDKNGICIDSILKLGFSFIEIGTITPKPQKGNNKPRIFRDVENKSIINACGFNNIGCDKVTENLINFRKKQEEDKLLSKHIVGVSIGKNKHTENIVDDLKYSIYKIARYADYIAINVSSPNTPGLRDNQESNKLKNIILFVKQEINKIEQIGHNGETFWMNTIKKKPLVFVKLAPDLENSEKKKIAQVLLDTGIDGMIISNTTINKMDIKSFEDKKGGVSGKKLKDLSTNLISDMYIYTNKQIPIIASGGILTGADALEKIEAGASVCQLYSCLVFNGVKSAIQIKREFNNALYQKGYYNLREAIGKKHSNAKSLKV
  
Inhibitor
Name:
BDBM120364
Synonyms:
US8703811, 4
Type:
Small organic molecule
Emp. Form.:
C15H9ClFIN2
Mol. Mass.:
398.601
SMILES:
Fc1cc(I)ccc1Nc1ccnc2cc(Cl)ccc12
Structure:
Search PDB for entries with ligand similarity: