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Target
Integrin-linked protein kinase
Ligand
BDBM123996
Substrate
n/a
Meas. Tech.
In Vitro Ezyme Assay
Temperature
313.15±n/a K
IC50
70±n/a nM
Comments
extracted
Citation
 Zhang, Z; Daynard, TS; Wang, S; Du, X; Chopiuk, GB; Yan, J; Chen, J; Sviridov, SV Pyrazolylbenzothiazole derivatives and their use as therapeutic agents US Patent  US8754233 Publication Date 6/17/2014
Target
Name:
Integrin-linked protein kinase
Synonyms:
ILK | ILK1 | ILK2 | ILK_HUMAN | Integrin-linked protein kinase (ILK) | Serine/threonine-protein kinase ILK-1
Type:
Protein
Mol. Mass.:
51429.75
Organism:
Homo sapiens (Human)
Description:
Q13418
Residue:
452
Sequence:
MDDIFTQCREGNAVAVRLWLDNTENDLNQGDDHGFSPLHWACREGRSAVVEMLIMRGARINVMNRGDDTPLHLAASHGHRDIVQKLLQYKADINAVNEHGNVPLHYACFWGQDQVAEDLVANGALVSICNKYGEMPVDKAKAPLRELLRERAEKMGQNLNRIPYKDTFWKGTTRTRPRNGTLNKHSGIDFKQLNFLTKLNENHSGELWKGRWQGNDIVVKVLKVRDWSTRKSRDFNEECPRLRIFSHPNVLPVLGACQSPPAPHPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMARGMAFLHTLEPLIPRHALNSRSVMIDEDMTARISMADVKFSFQCPGRMYAPAWVAPEALQKKPEDTNRRSADMWSFAVLLWELVTREVPFADLSNMEIGMKVALEGLRPTIPPGISPHVCKLMKICMNEDPAKRPKFDMIVPILEKMQDK
  
Inhibitor
Name:
BDBM123996
Synonyms:
US8754233, 4-(5-Fluoro-6-methoxy-benzothiazol-2-yl)-5-piperazin-1-yl-2H-pyrazol-3-ylamine
Type:
Small organic molecule
Emp. Form.:
C15H17FN6OS
Mol. Mass.:
348.398
SMILES:
COc1cc2sc(nc2cc1F)-c1c(N)n[nH]c1N1CCNCC1
Structure:
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