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Target
Tyrosine-protein phosphatase non-receptor type 1
Ligand
BDBM124252
Substrate
n/a
IC50
3.25e+3± 8.5e+2 nM
Citation
 Yin, JP; Tang, CL; Gao, LX; Ma, WP; Li, JY; Li, Y; Li, J; Nan, FJ Design and synthesis of paracaseolide A analogues as selective protein tyrosine phosphatase 1B inhibitors. Org Biomol Chem 12:3441-5 (2014) [PubMed]  Article
Target
Name:
Tyrosine-protein phosphatase non-receptor type 1
Synonyms:
PTN1_HUMAN | PTP1B | PTPN1 | Protein tyrosine phosphatase 1B (PTP1B) | Protein tyrosine phosphatase-1B (PTP1B) | Protein-tyrosine phosphatase 1B | Protein-tyrosine phosphatase 1B (PTP1B) | Tyrosine-protein phosphatase non-receptor type 1 | Tyrosine-protein phosphatase non-receptor type 1 (PTP1B)
Type:
Protein phosphatase
Mol. Mass.:
49963.76
Organism:
Homo sapiens (Human)
Description:
Human recombinant GST-fusion PTP1B (1-435).
Residue:
435
Sequence:
MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLEPPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYGIESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLTAGAYLCYRFLFNSNT
  
Inhibitor
Name:
BDBM124252
Synonyms:
(1R,2S,3S,8R,9S,12S)-8-dodecyl-3,12-dimethyl-9-[(1E)-tetradec-1-en-1-yl]-4,11-dioxatricyclo[7.3.0.0,⁶]dodec-6-ene-5,10-dione (6)
Type:
Small organic molecule
Emp. Form.:
C38H64O4
Mol. Mass.:
584.9124
SMILES:
CCCCCCCCCCCC\C=C\[C@]12[C@H]([C@H](C)OC1=O)[C@@H]1[C@H](C)OC(=O)C1=C[C@H]2CCCCCCCCCCCC |r,c:29|
Structure:
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