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Target
Vasopressin V2 receptor
Ligand
BDBM192474
Substrate
n/a
Meas. Tech.
Cellular In Vitro Assay
Temperature
310.15±n/a K
IC50
5.80±n/a nM
Comments
extracted
Citation
 Fürstner, C; Keldenich, J; Delbeck, M; Kolkhof, P; Kretschmer, A; Pluschkell, I; Pook, E; Schmeck, C; Trübel, H Bisaryl-bonded aryltriazolones and use thereof US Patent  US9687476 Publication Date 6/27/2017
Target
Name:
Vasopressin V2 receptor
Synonyms:
ADHR | AVPR V2 | AVPR2 | Antidiuretic hormone receptor | DIR | DIR3 | Renal-type arginine vasopressin receptor | V2R | V2R_HUMAN | VASOPRESSIN V2 | Vasopressin V2 receptor | Vasopressin receptor
Type:
Receptor
Mol. Mass.:
40295.28
Organism:
Homo sapiens (Human)
Description:
P30518
Residue:
371
Sequence:
MLMASTTSAVPGHPSLPSLPSNSSQERPLDTRDPLLARAELALLSIVFVAVALSNGLVLAALARRGRRGHWAPIHVFIGHLCLADLAVALFQVLPQLAWKATDRFRGPDALCRAVKYLQMVGMYASSYMILAMTLDRHRAICRPMLAYRHGSGAHWNRPVLVAWAFSLLLSLPQLFIFAQRNVEGGSGVTDCWACFAEPWGRRTYVTWIALMVFVAPTLGIAACQVLIFREIHASLVPGPSERPGGRRRGRRTGSPGEGAHVSAAVAKTVRMTLVIVVVYVLCWAPFFLVQLWAAWDPEAPLEGAPFVLLMLLASLNSCTNPWIYASFSSSVSSELRSLLCCARGRTPPSLGPQDESCTTASSSLAKDTSS
  
Inhibitor
Name:
BDBM192474
Synonyms:
US9187466, 135 | US9687476, 135
Type:
Small organic molecule
Emp. Form.:
C25H19Cl2F3N4O3
Mol. Mass.:
551.345
SMILES:
NC(=O)c1ccc(cc1Cn1nc(-c2ccc(Cl)cc2)n(CC(O)C(F)(F)F)c1=O)-c1ccccc1Cl
Structure:
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