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Target
VIM-24
Ligand
BDBM153701
Substrate
n/a
Meas. Tech.
Direct Competition Assay
Ki
1.2e+4± 3e+3 nM
Citation
 Mojica, MF; Mahler, SG; Bethel, CR; Taracila, MA; Kosmopoulou, M; Papp-Wallace, KM; Llarrull, LI; Wilson, BM; Marshall, SH; Wallace, CJ; Villegas, MV; Harris, ME; Vila, AJ; Spencer, J; Bonomo, RA Exploring the Role of Residue 228 in Substrate and Inhibitor Recognition by VIM Metallo-ß-lactamases. Biochemistry 54:3183-96 (2015) [PubMed]  Article
Target
Name:
VIM-24
Synonyms:
Metallo-beta-lactamase VIM-24 (VIM-24)
Type:
Protein
Mol. Mass.:
28273.97
Organism:
Klebsiella pneumoniae (Enterobacteria)
Description:
E0AFT6
Residue:
266
Sequence:
MFKLLSKLLVYLTASIMAIASPLAFSVDSSGEYPTVSEIPVGEVRLYQIADGVWSHIATQSFDGAVYPSNGLIVRDGDELLLIDTAWGAKNTAALLAEIEKQIGLPVTRAVSTHFHDDRVGGVDVLRAAGVATYASPSTRRLAEVEGNEIPTHSLEGLSSSGDAVRFGPVELFYPGAAHSTDNLVVYVPSASVLYGGCAIYELSLTSAGNVADADLAEWPTSIERIQQHYPEAQFVIPGHGLPGGLDLLKHTTNVVKAHTNRSVVE
  
Inhibitor
Name:
BDBM153701
Synonyms:
D-VC26
Type:
Small organic molecule
Emp. Form.:
C9H15NO2S3
Mol. Mass.:
265.416
SMILES:
CC1(C)S[C@@H]2CS[C@@H](CS)N2[C@H]1C(O)=O |r|
Structure:
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