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Target
Amyloid-beta precursor protein
Ligand
BDBM155395
Substrate
n/a
Meas. Tech.
Fluorescence (or Forster) Resonance Energy Transfer (FRET) Assay
pH
8±n/a
Temperature
310.15±n/a K
IC50
3200±n/a nM
Comments
extracted
Citation
 Krafft, GA; Pray, T; Goure, WF Methods of modifying amyloid β oligomers using non-peptidic compounds US Patent  US9006283 Publication Date 4/14/2015
Target
Name:
Amyloid-beta precursor protein
Synonyms:
A4 | A4_RAT | AD1 | App | Beta-amyloid protein 42
Type:
Protein
Mol. Mass.:
86651.28
Organism:
Rattus norvegicus (Rat)
Description:
P08592
Residue:
770
Sequence:
MLPSLALLLLAAWTVRALEVPTDGNAGLLAEPQIAMFCGKLNMHMNVQNGKWESDPSGTKTCIGTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHTHIVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDSIDSADAEEDDSDVWWGGADTDYADGGEDKVVEVAEEEEVADVEEEEAEDDEDVEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSVSSQSLLKTTSEPLPQDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPHHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHPFGVDSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAEFGHDSGFEVRHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
  
Inhibitor
Name:
BDBM155395
Synonyms:
US9006283, 5
Type:
Small organic molecule
Emp. Form.:
C17H20F3N3O4
Mol. Mass.:
387.3536
SMILES:
COc1ccccc1NC(=O)C(=O)N1N=C(CC(C)C)CC1(O)C(F)(F)F |t:15|
Structure:
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