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Target
5-hydroxytryptamine receptor 3A
Ligand
BDBM160711
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay
pH
7.5±n/a
Temperature
298.15±n/a K
Ki
5±n/a nM
Comments
extracted
Citation
 Guzzo, PR; Manning, DD; Earley, W 5-HT3 receptor modulators, methods of making, and use thereof US Patent  US9045501 Publication Date 6/2/2015
Target
Name:
5-hydroxytryptamine receptor 3A
Synonyms:
5-HT-3 | 5-HT3 | 5-HT3A | 5-HT3R | 5-hydroxytryptamine receptor 3 (5-HT3) | 5-hydroxytryptamine receptor 3A (5-HT3a) | 5-hydroxytryptamine receptor 3A (5HT3A) | 5HT3A_HUMAN | 5HT3R | HTR3 | HTR3A | Serotonin 3 (5-HT3) receptor | Serotonin 3 receptor (5HT3) | Serotonin receptor 3A | Serotonin-gated ion channel receptor | Serotonin-gated ion channel receptor 3
Type:
Protein
Mol. Mass.:
55283.27
Organism:
Homo sapiens (Human)
Description:
P46098
Residue:
478
Sequence:
MLLWVQQALLALLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSMESSNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQQPVPAWLRHLVLERIAWLLCLREQSTSQRPPATSQATKTDDCSAMGNHCSHMGGPQDFEKSPRDRCSPPPPPREASLAVCGLLQELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLAVLAYSITLVMLWSIWQYA
  
Inhibitor
Name:
BDBM160711
Synonyms:
US9045501, 3
Type:
Small organic molecule
Emp. Form.:
C19H23N3O
Mol. Mass.:
309.4054
SMILES:
Cc1cn2CCN([C@@H]3CN4CCC3CC4)C(=O)c3cccc1c23 |r,wD:7.6,(2.64,-5.58,;2.16,-4.12,;3.03,-2.83,;2.12,-1.59,;2.55,.21,;1.59,1.41,;.05,1.41,;-.72,2.75,;-2.26,2.75,;-3.03,4.08,;-2.26,5.41,;-.72,5.41,;.05,4.08,;-1.28,3.31,;-1.7,4.85,;-.91,.21,;-2.4,.61,;-.67,-1.29,;-2.01,-2.06,;-2.01,-3.6,;-.68,-4.37,;.66,-3.6,;.66,-2.06,)|
Structure:
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