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Target
Arachidonate 5-lipoxygenase-activating protein
Ligand
BDBM166934
Substrate
n/a
Meas. Tech.
Homogeneous Time Resolved Fluorescence Assay
Ki
5±n/a nM
Citation
 Eccles, W; Fitzgerald, AE; Hack, MD; Hawryluk, NA; Jones, WM; Keith, JM; Krawczuk, P; Lebsack, AD; Liu, J; Mani, NS; McClure, KJ; Meduna, SP; Rosen, MD Flap modulators US Patent  US9073876 Publication Date 7/7/2015
Target
Name:
Arachidonate 5-lipoxygenase-activating protein
Synonyms:
5-lipoxygenase activating protein | 5-lipoxygenase-activating protein (FLAP) | 5-lipoxygenase/FLAP | AL5AP_HUMAN | ALOX5AP | FLAP | MK-886-binding protein
Type:
Enzyme
Mol. Mass.:
18159.90
Organism:
Homo sapiens (Human)
Description:
P20292
Residue:
161
Sequence:
MDQETVGNVVLLAIVTLISVVQNGFFAHKVEHESRTQNGRSFQRTGTLAFERVYTANQNCVDAYPTFLAVLWSAGLLCSQVPAAFAGLMYLFVRQKYFVGYLGERTQSTPGYIFGKRIILFLFLMSVAGIFNYYLIFFFGSDFENYIKTISTTISPLLLIP
  
Inhibitor
Name:
BDBM166934
Synonyms:
US9073876, 20 | US9732093, Compound 20
Type:
Small organic molecule
Emp. Form.:
C22H20FN7O
Mol. Mass.:
417.4389
SMILES:
Nc1cnc(cn1)-c1ccc(C2CCC2)c(OCc2ccc(cc2)-c2nnn[nH]2)c1F
Structure:
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