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Target
Poly [ADP-ribose] polymerase tankyrase-1 [1068-1325]
Ligand
BDBM192899
Substrate
n/a
Meas. Tech.
Chemiluminescent PARP Assay
IC50
21±n/a nM
Citation
 Ashworth, A; Lord, CJ; Elliot, RJ; Niculescu-Duvaz, D; Porter, R; Boffey, RJ; Bayford, MJ; Firth-Clark, S; Jarvis, AN; Perrior, TR; Key, RE 3-aryl-5-substituted-isoquinolin-1-one compounds and their therapeutic use US Patent  US9193689 Publication Date 11/24/2015
Target
Name:
Poly [ADP-ribose] polymerase tankyrase-1 [1068-1325]
Synonyms:
PARP5A | PARPL | TIN1 | TINF1 | TNKS | TNKS1 | TNKS1_HUMAN | Tankyrase-1 (TNKS1)
Type:
Protein
Mol. Mass.:
29381.76
Organism:
Homo sapiens (Human)
Description:
PDB: 2RF5
Residue:
258
Sequence:
MHHHHHHSSGVDLGTENLYFQSMQGTNPYLTFHCVNQGTILLDLAPEDKEYQSVEEEMQSTIREHRDGGNAGGIFNRYNVIRIQKVVNKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYICHRQMLFCRVTLGKSFLQFSTIKMAHAPPGHHSVIGRPSVNGLAYAEYVIYRGEQAYPEYLITYQIMKPEAPSQTATAAEQ
  
Inhibitor
Name:
BDBM192899
Synonyms:
US9193689, IQ-003
Type:
Small organic molecule
Emp. Form.:
C20H22N4O
Mol. Mass.:
334.4149
SMILES:
CN1CCN(CC1)c1ccc(cn1)-c1cc2c(C)cccc2c(=O)[nH]1
Structure:
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