Reaction Details  Report a problem with these data
Target
Hypoxanthine-guanine-xanthine phosphoribosyltransferase
Ligand
BDBM194496
Substrate
n/a
Meas. Tech.
Spectrophotometric Assay
pH
7.4±n/a
Ki
200±30 nM
Comments
extracted
Citation
 De Jersey, J; Guddat, LW; Hockova, D; Keough, DT 6-oxopurine phosphoribosyltransferase inhibitors US Patent  US9200020 Publication Date 12/1/2015
Target
Name:
Hypoxanthine-guanine-xanthine phosphoribosyltransferase
Synonyms:
HGXR_PLAFG | Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) | Hypoxanthine-guanine-xanthine phosphoribosyltransferase (PfHGXPRT) | LACZ
Type:
Protein
Mol. Mass.:
26352.14
Organism:
Plasmodium falciparum
Description:
P20035
Residue:
231
Sequence:
MPIPNNPGAGENAFDPVFVNDDDGYDLDSFMIPAHYKKYLTKVLVPNGVIKNRIEKLAYDIKKVYNNEEFHILCLLKGSRGFFTALLKHLSRIHNYSAVETSKPLFGEHYVRVKSYCNDQSTGTLEIVSEDLSCLKGKHVLIVEDIIDTGKTLVKFCEYLKKFEIKTVAIACLFIKRTPLWNGFKADFVGFSIPDHFVVGYSLDYNEIFRDLDHCCLVNDEGKKKYKATSL
  
Inhibitor
Name:
BDBM194496
Synonyms:
US9200020, Table 3 compound 5
Type:
Small organic molecule
Emp. Form.:
C12H19N7O4P
Mol. Mass.:
356.2975
SMILES:
Nc1nc2n(CCN(CCC#N)CCP(O)(O)=O)c[nH]c2c(=O)[nH]1
Structure:
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