Reaction Details 
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Flap endonuclease 1 [1-336]
Ligand
BDBM197161
Substrate
n/a
Meas. Tech.
Steady-State Kinetics
pH
7.5±n/a
IC50
30.0±6.0 nM
Comments
extracted
Citation
Exell, JC; Thompson, MJ; Finger, LD; Shaw, SJ; Debreczeni, J; Ward, TA; McWhirter, C; Siöberg, CL; Martinez Molina, D; Abbott, WM; Jones, CD; Nissink, JW; Durant, ST; Grasby, JA Cellularly active N-hydroxyurea FEN1 inhibitors block substrate entry to the active site. Nat Chem Biol 12:815-21 (2016) [PubMed] ArticleMore Info.:
Target
Name:
Flap endonuclease 1 [1-336]
Synonyms:
FEN1 | FEN1_HUMAN | Flap endonuclease 1 (aa 1-336) | RAD2
Type:
Protein
Mol. Mass.:
37858.07
Organism:
Homo sapiens (Human)
Description:
C-terminally truncated after residue 336
Residue:
336
Sequence:
MGIQGLAKLIADVAPSAIRENDIKSYFGRKVAIDASMSIYQFLIAVRQGGDVLQNEEGETTSHLMGMFYRTIRMMENGIKPVYVFDGKPPQLKSGELAKRSERRAEAEKQLQQAQAAGAEQEVEKFTKRLVKVTKQHNDECKHLLSLMGIPYLDAPSEAEASCAALVKAGKVYAAATEDMDCLTFGSPVLMRHLTASEAKKLPIQEFHLSRILQELGLNQEQFVDLCILLGSDYCESIRGIGPKRAVDLIQKHKSIEEIVRRLDPNKYPVPENWLHKEAHQLFLEPEVLDPESVELKWSEPNEEELIKFMCGEKQFSEERIRSGVKRLSKSRQGST
Inhibitor
Name:
BDBM197161
Synonyms:
1-(cyclopropylmethyl)-3-hydroxyquinazoline-2,4(1H,3H)-dione (2)
Type:
Small organic molecule
Emp. Form.:
C12H12N2O3
Mol. Mass.:
232.2353
SMILES:
On1c(=O)n(CC2CC2)c2ccccc2c1=O
Structure:
