Reaction Details
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Target
Tyrosine-protein kinase ITK/TSK [357-620,Y512E]
Ligand
BDBM213221
Substrate
n/a
Meas. Tech.
LanthaScreen Kinase Binding Assay
IC50
6.3±0 nM
Citation
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More Info.:
Target
Name:
Tyrosine-protein kinase ITK/TSK [357-620,Y512E]
Synonyms:
EMT | ITK | ITK_HUMAN | Interlukin-2-inducible tyrosine kinase (Itk) | LYK
Type:
Enzyme
Mol. Mass.:
30027.99
Organism:
Homo sapiens (Human)
Description:
Human Itk truncation (357-620 aa) with Y512E mutation
Residue:
264
Sequence:
VIDPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQETSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPEDRPAFSRLLRQLAEIAESGL
Inhibitor
Name:
BDBM213221
Synonyms:
(S)-1-(3-((4-(Piperidin-1-ylmethyl)-6-(thiazolo[5,4-b]pyridin-2-ylamino)pyridin-2-yl)amino)pyrrolidin-1-yl)prop-2-en-1-one (10)
Type:
Small organic molecule
Emp. Form.:
C24H29N7OS
Mol. Mass.:
463.598
SMILES:
C=CC(=O)N1CC[C@@H](C1)Nc1cc(CN2CCCCC2)cc(Nc2nc3cccnc3s2)n1 |r|