Reaction Details  Report a problem with these data
Target
Serine protease 1
Ligand
BDBM233164
Substrate
BDBM233015
Meas. Tech.
Antiamidolytic Assay
IC50
2.0e+4± 1.6e+3 nM
Citation
 Drozdowska, D; Bruzgo, I; Midura-Nowaczek, K Carbocyclic potential DNA minor groove binders and their biological evaluation. J Enzyme Inhib Med Chem 25:629-34 (2010) [PubMed]  Article
Target
Name:
Serine protease 1
Synonyms:
Alpha-trypsin chain 1 | Alpha-trypsin chain 2 | Beta-trypsin | Cationic trypsinogen | PRSS1 | Serine protease 1 | TRP1 | TRY1 | TRY1_HUMAN | TRYP1 | Thrombin & trypsin | Trypsin | Trypsin I | Trypsin-1
Type:
Enzyme
Mol. Mass.:
26557.80
Organism:
Homo sapiens (Human)
Description:
P07477
Residue:
247
Sequence:
MNPLLILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSLNSGYHFCGGSLINEQWVVSAGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVINARVSTISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKITSNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWGDGCAQKNKPGVYTKVYNYVKWIKNTIAANS
  
Inhibitor
Name:
BDBM233164
Synonyms:
Carbocyclic minor groove binder, 6
Type:
Small organic molecule
Emp. Form.:
C33H34N6O4
Mol. Mass.:
578.6609
SMILES:
Nc1cccc(c1)C(=O)Nc1cccc(c1)C(=O)NCCCCCNC(=O)c1cccc(NC(=O)c2cccc(N)c2)c1
Structure:
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Substrate
Name:
BDBM233015
Synonyms:
Bzl-L-Arg-pNA⋅HCl
Type:
Small organic molecule
Emp. Form.:
C19H24N6O3
Mol. Mass.:
384.4323
SMILES:
NC(=N)NCCC[C@H](NCc1ccccc1)C(=O)Nc1ccc(cc1)[N+]([O-])=O |r|
Structure:
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