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Target
Rho-associated protein kinase 2 [1-552]
Ligand
BDBM50382684
Substrate
n/a
Meas. Tech.
FRET-Based Enzyme-Coupled Assay
pH
7.5±n/a
Temperature
298.15±n/a K
IC50
100±30 nM
Comments
extracted
Citation
 Schonbrunn, E; Li, R; Sebti, SM Inhibitors of rho associated protein kinases (ROCK) and methods of use US Patent  US9409868 Publication Date 8/9/2016
Target
Name:
Rho-associated protein kinase 2 [1-552]
Synonyms:
KIAA0619 | ROCK2 | ROCK2_HUMAN | Rho-associated protein kinase 2 (ROCK2)
Type:
Enzyme
Mol. Mass.:
63353.50
Organism:
Homo sapiens (Human)
Description:
aa 1-552
Residue:
552
Sequence:
MSRPPPTGKMPGAPETAPGDGAGASRQRKLEALIRDPRSPINVESLLDGLNSLVLDLDFPALRKNKNIDNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFFKNDQWHWDNIRETAAPVVPELSSDIDSSNFDDIEDDKGDVETFPIPKAFVGNQLPFIGFTYYRENLLLSDSPSCRETDSIQSRKNEESQEIQKKLYTLEEHLSNEMQAKEELEQKCKSVNTRLEKTAKELEEEITLRKSVESALRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQLEDLKKRNQNSQI
  
Inhibitor
Name:
BDBM50382684
Synonyms:
CHEMBL2023158 | US9409868, 24
Type:
Small organic molecule
Emp. Form.:
C20H19N3O2
Mol. Mass.:
333.3838
SMILES:
OC[C@@H](NC(=O)Nc1ccc(cc1)-c1ccncc1)c1ccccc1 |r|
Structure:
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