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Target
Proto-oncogene tyrosine-protein kinase Src
Ligand
BDBM50379221
Substrate
n/a
Meas. Tech.
Kinase Assay
pH
7.5±n/a
Temperature
303.15±n/a K
IC50
>100000±n/a nM
Comments
extracted
Citation
 Burnet, MW; Thaher, BA; Ehlert, J; Kubbutat, M; Schaechtele, C; Totzke, F Kinase modulators for the treatment of cancer US Patent  US9416123 Publication Date 8/16/2016
Target
Name:
Proto-oncogene tyrosine-protein kinase Src
Synonyms:
Calmodulin/Proto-oncogene tyrosine-protein kinase Src | Protein cereblon/Tyrosine-protein kinase SRC | Proto-oncogene c-Src | Proto-oncogene tyrosine-protein kinase Src (c-Src) | SRC | SRC1 | SRC_HUMAN | Tyrosine-protein kinase Src (SRC) | V-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | c-Src | p60-Src | pp60c-src
Type:
Protein
Mol. Mass.:
59838.60
Organism:
Homo sapiens (Human)
Description:
P12931
Residue:
536
Sequence:
MGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAEPKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
  
Inhibitor
Name:
BDBM50379221
Synonyms:
CHEMBL2011300 | US9416123, 15
Type:
Small organic molecule
Emp. Form.:
C17H13Cl3N4O2
Mol. Mass.:
411.67
SMILES:
CCOC(=O)c1c(N)n(nc1-c1ccncc1)-c1c(Cl)cc(Cl)cc1Cl |(15.66,-51.66,;16.99,-52.43,;18.32,-51.66,;19.66,-52.43,;19.66,-53.97,;20.99,-51.66,;22.46,-52.13,;22.93,-53.6,;23.37,-50.89,;22.46,-49.64,;20.99,-50.12,;19.75,-49.21,;19.73,-47.68,;18.38,-46.92,;17.06,-47.71,;17.08,-49.26,;18.43,-50,;24.91,-50.89,;25.67,-49.57,;24.89,-48.23,;27.2,-49.56,;27.98,-50.9,;29.52,-50.9,;27.21,-52.23,;25.67,-52.23,;24.9,-53.56,)|
Structure:
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