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Target
Tyrosine-protein kinase JAK1 [866-1154]
Ligand
BDBM410174
Substrate
n/a
Meas. Tech.
Caliper mobility shift assay
IC50
10.00±n/a nM
Citation
 Gauvry, N; Tahtaoui, C; Furet, P; Ducray, P Heterocyclyl-substituted cyclohexylsulfonamides as JAK inhibitors US Patent  US10370375 Publication Date 8/6/2019
Target
Name:
Tyrosine-protein kinase JAK1 [866-1154]
Synonyms:
JAK1 | JAK1 (aa 866-1154) | JAK1A | JAK1B | JAK1_HUMAN | Tyrosine-protein kinase JAK1 | Tyrosine-protein kinase JAK1 (aa 866-1154)
Type:
Protein
Mol. Mass.:
33185.74
Organism:
Homo sapiens (Human)
Description:
P23458[866-1154]
Residue:
289
Sequence:
DPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK
  
Inhibitor
Name:
BDBM410174
Synonyms:
US10370375, Example 22
Type:
Small organic molecule
Emp. Form.:
C16H21N5O2S
Mol. Mass.:
347.435
SMILES:
CNS(=O)(=O)C[C@H]1CCC(CC1)n1cnc2cnc3[nH]ccc3c12 |r,wD:6.5,(4.29,4.1,;4.29,5.64,;2.96,6.41,;1.63,7.18,;4.29,7.18,;2.96,4.87,;1.63,4.1,;.29,4.87,;-1.04,4.1,;-1.04,2.56,;.29,1.79,;1.63,2.56,;-2.38,1.79,;-3.62,1.79,;-4.25,.38,;-2.96,-.73,;-2.96,-2.27,;-1.63,-3.04,;-.29,-2.27,;1.17,-2.75,;2.08,-1.5,;1.17,-.25,;-.29,-.73,;-1.63,.04,)|
Structure:
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