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Target
Non-receptor tyrosine-protein kinase TNK1
Ligand
BDBM419774
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
12.6±n/a nM
Citation
 Lee, H; Chun, K; Joe, B; Kim, ES; Jang, ES; Oh, H; Kim, J; Park, J; Lee, H Tricyclic derivative compound, method for preparing same, and pharmaceutical composition comprising same US Patent  US10464919 Publication Date 11/5/2019
Target
Name:
Non-receptor tyrosine-protein kinase TNK1
Synonyms:
Non-receptor tyrosine-protein kinase TNK1 | TNK1 | TNK1_HUMAN
Type:
PROTEIN
Mol. Mass.:
72495.61
Organism:
Homo sapiens (Human)
Description:
ChEMBL_774410
Residue:
666
Sequence:
MLPEAGSLWLLKLLRDIQLAQFYWPILEELNVTRPEHFDFVKPEDLDGIGMGRPAQRRLSEALKRLRSGPKSKNWVYKILGGFAPEHKEPTLPSDSPRHLPEPEGGLKCLIPEGAVCRGELLGSGCFGVVHRGLWTLPSGKSVPVAVKSLRVGPEGPMGTELGDFLREVSVMMNLEHPHVLRLHGLVLGQPLQMVMELAPLGSLHARLTAPAPTPPLLVALLCLFLRQLAGAMAYLGARGLVHRDLATRNLLLASPRTIKVADFGLVRPLGGARGRYVMGGPRPIPYAWCAPESLRHGAFSSASDVWMFGVTLWEMFSGGEEPWAGVPPYLILQRLEDRARLPRPPLCSRALYSLALRCWAPHPADRPSFSHLEGLLQEAGPSEACCVRDVTEPGALRMETGDPITVIEGSSSFHSPDSTIWKGQNGRTFKVGSFPASAVTLADAGGLPATRPVHRGTPARGDQHPGSIDGDRKKANLWDAPPARGQRRNMPLERMKGISRSLESVLSLGPRPTGGGSSPPEIRQARAVPQGPPGLPPRPPLSSSSPQPSQPSRERLPWPKRKPPHNHPMGMPGARKAAALSGGLLSDPELQRKIMEVELSVHGVTHQECQTALGATGGDVVSAIRNLKVDQLFHLSSRSRADCWRILEHYQWDLSAASRYVLARP
  
Inhibitor
Name:
BDBM419774
Synonyms:
US10464919, Example 112
Type:
Small organic molecule
Emp. Form.:
C25H26FN5O
Mol. Mass.:
431.5052
SMILES:
C[C@@H]1CN(CCN1Cc1ccc2c3NCCCc3c(=O)[nH]c2c1)c1ccc(C#N)c(F)c1 |r|
Structure:
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