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Target
ATP-sensitive inward rectifier potassium channel 1
Ligand
BDBM426051
Substrate
n/a
Meas. Tech.
Thallium Flux Assay
IC50
10.7±n/a nM
Citation
 deJesus, RK; Fu, Q; Jiang, J; Tang, H Inhibitors of the renal outer medullary potassium channel US Patent  US10513518 Publication Date 12/24/2019
Target
Name:
ATP-sensitive inward rectifier potassium channel 1
Synonyms:
ATP-regulated potassium channel ROM-K | ATP-regulated potassium channel ROMK | ATP-sensitive inward rectifier potassium channel 1 | Egl nine homolog 1 | KCNJ1 | KCNJ1_HUMAN | Potassium channel (ATP modulatory) | Potassium inwardly-rectifying channel, subfamily J, member 1 | ROMK1 | Renal Outer Medullary Potassium (ROMK1) | The Renal Outer Medullary Potassium (ROMK)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44809.08
Organism:
Homo sapiens (Human)
Description:
gi_223460826
Residue:
391
Sequence:
MNASSRNVFDTLIRVLTESMFKHLRKWVVTRFFGHSRQRARLVSKDGRCNIEFGNVEAQSRFIFFVDIWTTVLDLKWRYKMTIFITAFLGSWFFFGLLWYAVAYIHKDLPEFHPSANHTPCVENINGLTSAFLFSLETQVTIGYGFRCVTEQCATAIFLLIFQSILGVIINSFMCGAILAKISRPKKRAKTITFSKNAVISKRGGKLCLLIRVANLRKSLLIGSHIYGKLLKTTVTPEGETIILDQININFVVDAGNENLFFISPLTIYHVIDHNSPFFHMAAETLLQQDFELVVFLDGTVESTSATCQVRTSYVPEEVLWGYRFAPIVSKTKEGKYRVDFHNFSKTVEVETPHCAMCLYNEKDVRARMKRGYDNPNFILSEVNETDDTKM
  
Inhibitor
Name:
BDBM426051
Synonyms:
US10513518, Example 41
Type:
Small organic molecule
Emp. Form.:
C24H30N6O3
Mol. Mass.:
450.5334
SMILES:
Cc1cc(ccc1C(O)CN1CCC2(CCCN(C3=CC(=O)CC3)C2=O)CC1)-n1cnnn1 |t:19|
Structure:
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