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Target
Neuroepithelial cell-transforming 1
Ligand
BDBM50337910
Substrate
n/a
Meas. Tech.
Functional Uptake Assay (rNET)
IC50
74.0±n/a nM
Citation
 Shao, L; Wang, F; Malcolm, SC; Hewitt, MC; Bush, LR; Ma, J; Varney, MA; Campbell, U; Engel, SR; Hardy, LW; Koch, P; Campell, JE Cycloalkylamines as monoamine reuptake inhibitors US Patent  US10562878 Publication Date 2/18/2020
Target
Name:
Neuroepithelial cell-transforming 1
Synonyms:
Net1 | Q498M6_RAT
Type:
Protein
Mol. Mass.:
61816.50
Organism:
Rat
Description:
Q498M6
Residue:
541
Sequence:
MVAHDEIGGLLPIKRTIRVLDVNNQPFREQEEPSNKRVRPLGRVTSLANLISPVRNGAVRRFGQTIQSFTLRGDHRSPASTQKSFSRATVPTPTKRRSSALWSEMLDISMKESLTTREIKRQEAIYELSRGEQDLIEDLKLARKAYHDPMLKLSIMSEEELTHIFGDLDAYIPLHEDLLARIGEATKPDGTVEQIGHILVNWLPGLNAYRGYCSNQLAAKALLDQKKQDPRVQDFLQRCLESPFSRKLDLWSFLDIPRSRLVKYPLLLKEILRHTPKDHLDVQLLEKAILIIQEVLSDINLKKGESECQYYIDKLEYLDEKQKDPRIEASKVLLCHGELKNKSGHKLYIFLFQDILVLTRPVTRNERHSYQVYRQPIPVQELVLEDLQDGDVRMGGSFRGAFGNSDKAKNIFRVRFQDPSPGQSHTLQANDVFHKQQWFNCIRSAIAPFQRAASPLELQGLPDLHEECEENNPSAGNLRAQRRSCVLPGVMQVDHESVLECGSSVQTSEDTRNAKAHRPQHGLRRARDKAQLGGKKKETLV
  
Inhibitor
Name:
BDBM50337910
Synonyms:
(+/-)-1-(1-(3,4-dichlorophenyl)cyclohexyl)-N-methylethanamine | 1-(1-(3,4-dichlorophenyl)cyclohexyl)-N-methylethanamine | CHEMBL1684045 | CHEMBL1684057 | US10562878, Compound 108
Type:
Small organic molecule
Emp. Form.:
C15H21Cl2N
Mol. Mass.:
286.24
SMILES:
CNC(C)C1(CCCCC1)c1ccc(Cl)c(Cl)c1
Structure:
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