Reaction Details  Report a problem with these data
Target
Adenosine receptor A3
Ligand
BDBM434807
Substrate
n/a
Meas. Tech.
Binding Assays
Ki
3.49±1.84 nM
Citation
 Jacobson, KA; Tosh, DK; Salvemini, D A3 adenosine receptor agonists US Patent  US10577368 Publication Date 3/3/2020
Target
Name:
Adenosine receptor A3
Synonyms:
A3 adenosine receptor (hA3) | AA3R_HUMAN | ADORA3 | Adenosine A3 receptor (A3AR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36197.32
Organism:
Homo sapiens (Human)
Description:
P0DMS8
Residue:
318
Sequence:
MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKRVTTHRRIWLALGLCWLVSFLVGLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYFSFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFALSWLPLSIINCIIYFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLILKACVVCHPSDSLDTSIEKNSE
  
Inhibitor
Name:
BDBM434807
Synonyms:
US10577368, Compound MRS5698
Type:
Small organic molecule
Emp. Form.:
C28H23ClF2N6O3
Mol. Mass.:
564.97
SMILES:
CNC(=O)[C@]12CC1[C@H]([C@H](O)C2O)n1cnc2c(NCc3cccc(Cl)c3)nc(nc12)C#Cc1ccc(F)c(F)c1 |r|
Structure:
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