Reaction Details  Report a problem with these data
Target
Free fatty acid receptor 1
Ligand
BDBM168162
Substrate
n/a
Meas. Tech.
Calcium Flux Assay
Temperature
298.15±n/a K
EC50
8.00±n/a nM
Comments
extracted
Citation
 PubChem, PC; Meegalla, S; Huang, H; Player, MR Substituted pyrazines as GPR40 agonists US Patent  US9688642 Publication Date 6/27/2017
Target
Name:
Free fatty acid receptor 1
Synonyms:
FFAR1 | FFAR1_HUMAN | G-protein Coupled Receptor 40 | GPR40
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
31473.32
Organism:
Homo sapiens (Human)
Description:
O14842
Residue:
300
Sequence:
MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
  
Inhibitor
Name:
BDBM168162
Synonyms:
US9688642, 10
Type:
Small organic molecule
Emp. Form.:
C32H31FN2O4
Mol. Mass.:
526.5979
SMILES:
COc1ccc(F)c(c1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1-c1cc(C)cc(C)c1 |r|
Structure:
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