Reaction Details  Report a problem with these data
Target
Adenosine receptor A3
Ligand
BDBM458392
Substrate
n/a
Meas. Tech.
Competition Radioligand Binding Assay
Ki
65.5±n/a nM
Citation
 Castro Palomino Laria, J; Camacho Gómez, J; El Maatougui, A Adenosine A3 receptor modulators US Patent  US10744125 Publication Date 8/18/2020
Target
Name:
Adenosine receptor A3
Synonyms:
A3 adenosine receptor (hA3) | AA3R_HUMAN | ADORA3 | Adenosine A3 receptor (A3AR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36197.32
Organism:
Homo sapiens (Human)
Description:
P0DMS8
Residue:
318
Sequence:
MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKRVTTHRRIWLALGLCWLVSFLVGLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYFSFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFALSWLPLSIINCIIYFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLILKACVVCHPSDSLDTSIEKNSE
  
Inhibitor
Name:
BDBM458392
Synonyms:
US10744125, Example 3
Type:
Small organic molecule
Emp. Form.:
C23H21N5O4S
Mol. Mass.:
463.509
SMILES:
COc1cccc(c1)-c1nc(NC(=O)c2ccc(nc2)N2CCC(CC2)C(O)=O)sc1C#N
Structure:
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