Reaction Details  Report a problem with these data
Target
Tyrosine-protein kinase Fyn
Ligand
BDBM473184
Substrate
n/a
Meas. Tech.
Radioisotope Filter Binding Assay
IC50
52±n/a nM
Citation
 Mansour, TS; Evans, CE 1,2-dithiolane compounds useful in neuroprotection, autoimmune and cancer diseases and conditions US Patent  US10844038 Publication Date 11/24/2020
Target
Name:
Tyrosine-protein kinase Fyn
Synonyms:
FYN | FYN_HUMAN | Proto-oncogene Syn | Proto-oncogene c-Fyn | SLK | SRC | Src-like kinase | p59-Fyn
Type:
Enzyme
Mol. Mass.:
60762.21
Organism:
Homo sapiens (Human)
Description:
P06241
Residue:
537
Sequence:
MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL
  
Inhibitor
Name:
BDBM473184
Synonyms:
US10844038, Example 62 | trans 3-((4-Amino-3-(4-(2-fluorophenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-1,2-dithiolan-4-yl benzoate
Type:
Small organic molecule
Emp. Form.:
C28H22FN5O3S2
Mol. Mass.:
559.634
SMILES:
Nc1ncnc2n(CC3SSCC3OC(=O)c3ccccc3)nc(-c3ccc(Oc4ccccc4F)cc3)c12
Structure:
Search PDB for entries with ligand similarity: