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Target
Prolyl hydroxylase EGLN3
Ligand
BDBM477231
Substrate
n/a
Meas. Tech.
EGLN-1 Activity Assay
IC50
221±19.2 nM
Citation
 You, Q; Zhang, X; Lei, Y; Hu, T; Wu, X; Sun, H; Guo, X; Xu, X Alkynyl pyridine prolyl hydroxylase inhibitor, and preparation method and medical use thereof US Patent  US10889546 Publication Date 1/12/2021
Target
Name:
Prolyl hydroxylase EGLN3
Synonyms:
EGLN3 | EGLN3_HUMAN | Egl nine homolog 3 (EGLIN3) | Egl nine homolog 3 (EGLN3)
Type:
Protein
Mol. Mass.:
27265.54
Organism:
Homo sapiens (Human)
Description:
Q9H6Z9
Residue:
239
Sequence:
MPLGHIMRLDLEKIALEYIVPCLHEVGFCYLDNFLGEVVGDCVLERVKQLHCTGALRDGQLAGPRAGVSKRHLRGDQITWIGGNEEGCEAISFLLSLIDRLVLYCGSRLGKYYVKERSKAMVACYPGNGTGYVRHVDNPNGDGRCITCIYYLNKNWDAKLHGGILRIFPEGKSFIADVEPIFDRLLFFWSDRRNPHEVQPSYATRYAMTVWYFDAEERAEAKKKFRNLTRKTESALTED
  
Inhibitor
Name:
BDBM477231
Synonyms:
US10889546, Example 40
Type:
Small organic molecule
Emp. Form.:
C21H22N2O6
Mol. Mass.:
398.4092
SMILES:
CC(C)(C)Oc1cccc(OCC#Cc2cnc(C(=O)NCC(O)=O)c(O)c2)c1
Structure:
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