Target

Ligand

Substrate

Meas. Tech.

GSK-3 Inhibition Assay

Temperature

310.15±n/a K

Citation

 Martinez, A; Alonso, M; Castro, A; Perez, C; Moreno, FJ First non-ATP competitive glycogen synthase kinase 3 beta (GSK-3beta) inhibitors: thiadiazolidinones (TDZD) as potential drugs for the treatment of Alzheimer's disease. J Med Chem 45:1292-9 (2002) [PubMed]  Article

More Info.:

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Name:

Glycogen synthase kinase-3 beta [7-25]

Synonyms:

G1T8E2_RABIT | GSK-3, beta | GSK3B | Glycogen Synthase Kinase-3, beta

Type:

Enzyme fragment

Mol. Mass.:

1972.14

Organism:

Oryctolagus cuniculus (rabbit)

Description:

Glycogen Synthase Kinase-3 is the beta isoform of the rabbit enzyme produced in E.coli.. Only partial sequence is available.

Residue:

19

Sequence:

TTSFAESCKPVQQPSAFGS

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Blast E-value cutoff:

Name:

BDBM7799

Synonyms:

3-ethyl-1-[(5Z)-2-ethyl-3-oxo-4-phenyl-1,2,4-thiadiazolidin-5-ylidene]urea | Thiadiazolidinone (TDZD) deriv. 26 | ethyl-(2-ethyl-3-oxo-4-phenyl-1,2,4-thiadiazolidin-5-ylidene)urea

Type:

Small organic molecule

Emp. Form.:

C13H16N4O2S

Mol. Mass.:

292.357

SMILES:

CCNC(=O)\N=c1/sn(CC)c(=O)n1-c1ccccc1

Structure:

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Similarity to this molecule at least:

Name:

GSK-3 Peptide Substrate

Synonyms:

GS-1 Peptide | Phospho-GS2 Substrate Peptide

Type:

Peptide

Mol. Mass.:

3045.17

Organism:

n/a

Description:

n/a

Residue:

27

Sequence:

YRRAAVPPSPSLSRHSSPHQSPEDEEE