Reaction Details  Report a problem with these data
Target
Aurora kinase B
Ligand
BDBM50193016
Substrate
n/a
Meas. Tech.
In Vitro Kinase Assay
IC50
631±n/a nM
Citation
 Gray, NS; Zhang, T; Ferguson, FM; Zhao, J; Ni, J Pyrimido-diazepinone kinase scaffold compounds and methods for treating PI3K-mediated disorders US Patent  US11155556 Publication Date 10/26/2021
Target
Name:
Aurora kinase B
Synonyms:
AIK2 | AIM-1 | AIM1 | AIRK2 | ARK2 | AURKB | AURKB_HUMAN | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora kinase 2 | Aurora kinase B (AURKB) | Aurora-related kinase 2 | STK-1 | STK1 | STK12 | STK5 | Serine/threonine-protein kinase aurora B
Type:
Protein
Mol. Mass.:
39327.72
Organism:
Homo sapiens (Human)
Description:
Q96GD4
Residue:
344
Sequence:
MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMENSSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGAQDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
  
Inhibitor
Name:
BDBM50193016
Synonyms:
CHEMBL3889977 | US11155556, No. 3
Type:
Small organic molecule
Emp. Form.:
C28H31N7O4S
Mol. Mass.:
561.655
SMILES:
CN1c2ccc(C)cc2C(=O)N(C)c2cnc(Nc3cccc(c3)S(=O)(=O)N3CCC(CC3)NC(=O)C=C)nc12
Structure:
Search PDB for entries with ligand similarity: