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Target
Receptor-interacting serine/threonine-protein kinase 2
Ligand
BDBM303372
Substrate
n/a
Meas. Tech.
V9103X ADP-Glo Kinase Assay Custom
IC50
3.30±n/a nM
Citation
 Cui, J; Gao, DA; Liu, P; McKibben, BP; Miller, CA; Razavi, H; Spencer, E; Ruppel, S; Padyana, AK Substituted benzamides as RIPK2 inhibitors US Patent  US10138222 Publication Date 11/27/2018
Target
Name:
Receptor-interacting serine/threonine-protein kinase 2
Synonyms:
CARDIAK | RICK | RIP2 | RIPK2 | RIPK2_HUMAN | Serine/threonine-protein kinase RIPK2 | Tyrosine-protein kinase RIPK2 | receptor-interacting serine/threonine-protein kinase 2
Type:
Protein
Mol. Mass.:
61201.30
Organism:
Human
Description:
n/a
Residue:
540
Sequence:
MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM
  
Inhibitor
Name:
BDBM303372
Synonyms:
US10138222, Example 97
Type:
Small organic molecule
Emp. Form.:
C25H29N5O
Mol. Mass.:
415.5307
SMILES:
Cc1ccc(cc1-c1cnn(c1)-c1cncc(NC2CCCCC2)c1)C(=O)NC1CC1
Structure:
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