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Target
15-hydroxyprostaglandin dehydrogenase [NAD(+)]
Ligand
BDBM556311
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
12.8±n/a nM
Citation
 Rai, R; Booth, R; Green, MJ PGDH inhibitors and methods of making and using US Patent  US11345702 Publication Date 5/31/2022
Target
Name:
15-hydroxyprostaglandin dehydrogenase [NAD(+)]
Synonyms:
15-PGDH | 15-hydroxyprostaglandin dehydrogenase [NAD+] | HPGD | PGDH1 | PGDH_HUMAN | Prostaglandin dehydrogenase 1 (15-PGDH) | SDR36C1
Type:
Enzyme
Mol. Mass.:
28974.46
Organism:
Homo sapiens (Human)
Description:
P15428
Residue:
266
Sequence:
MHVNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFIQCDVADQQQLRDTFRKVVDHFGRLDILVNNAGVNNEKNWEKTLQINLVSVISGTYLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAANLMNSGVRLNAICPGFVNTAILESIEKEENMGQYIEYKDHIKDMIKYYGILDPPLIANGLITLIEDDALNGAIMKITTSKGIHFQDYDTTPFQAKTQ
  
Inhibitor
Name:
BDBM556311
Synonyms:
US11345702, Table 1.29 | US20230390274, Compound A-62
Type:
Small organic molecule
Emp. Form.:
C18H17ClN4O
Mol. Mass.:
340.807
SMILES:
Clc1cccc(c1)-n1cnc2cc(cnc12)C(=O)N1CCCCC1
Structure:
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