Reaction Details  Report a problem with these data
Target
15-hydroxyprostaglandin dehydrogenase [NAD(+)]
Ligand
BDBM556320
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
8.50±n/a nM
Citation
 Rai, R; Booth, R; Green, MJ PGDH inhibitors and methods of making and using US Patent  US11345702 Publication Date 5/31/2022
Target
Name:
15-hydroxyprostaglandin dehydrogenase [NAD(+)]
Synonyms:
15-PGDH | 15-hydroxyprostaglandin dehydrogenase [NAD+] | HPGD | PGDH1 | PGDH_HUMAN | Prostaglandin dehydrogenase 1 (15-PGDH) | SDR36C1
Type:
Enzyme
Mol. Mass.:
28974.46
Organism:
Homo sapiens (Human)
Description:
P15428
Residue:
266
Sequence:
MHVNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFIQCDVADQQQLRDTFRKVVDHFGRLDILVNNAGVNNEKNWEKTLQINLVSVISGTYLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAANLMNSGVRLNAICPGFVNTAILESIEKEENMGQYIEYKDHIKDMIKYYGILDPPLIANGLITLIEDDALNGAIMKITTSKGIHFQDYDTTPFQAKTQ
  
Inhibitor
Name:
BDBM556320
Synonyms:
US11345702, Table 2.3 | US20230390274, Compound A-71
Type:
Small organic molecule
Emp. Form.:
C20H22ClNO3
Mol. Mass.:
359.847
SMILES:
COc1cc(ccc1COc1ccccc1Cl)C(=O)N1CCCCC1
Structure:
Search PDB for entries with ligand similarity: