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Target
Glucagon-like peptide 1 receptor
Ligand
BDBM559784
Substrate
n/a
Meas. Tech.
GLP-1R ACTIVATION - cAMP Assay 1
IC50
0.24±n/a nM
Citation
 J., BG; S., CJ; Chienhung, C; J., CJ; Chao-I, H; Kavoos, K; G., TJ; E., WN; Zheng-Yu, Y POLYHETEROCYCLIC GLP-1 R MODULATING COMPOUNDS WIPO 0:0 (2022) [PubMed]
Target
Name:
Glucagon-like peptide 1 receptor
Synonyms:
GLP-1 receptor | GLP-1-R | GLP-1R | GLP1R | GLP1R_HUMAN | Glucagon-like peptide 1 receptor | Glucagon-like peptide 1 receptor (GLP-1)
Type:
Enzyme
Mol. Mass.:
53035.78
Organism:
Homo sapiens (Human)
Description:
P43220
Residue:
463
Sequence:
MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS
  
Inhibitor
Name:
BDBM559784
Synonyms:
WO2022109182, Example 15
Type:
Small organic molecule
Emp. Form.:
C32H30F2N6O3
Mol. Mass.:
584.6158
SMILES:
CC(C)(Cn1c(CN2CCC(CC2)c2cccc(OCc3ccc(cc3F)C#N)n2)nc2c(F)cc(cc12)C(O)=O)C#N
Structure:
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