Reaction Details Report a problem with these data
Target
Arginase-2, mitochondrial
Ligand
BDBM290404
Substrate
n/a
IC50
125±n/a nM
Citation
Van Zandt, M; Jagdmann, GE Arginase inhibitors as therapeutics US Patent US11389464 Publication Date 7/19/2022
More Info.:
Target
Name:
Arginase-2, mitochondrial
Synonyms:
ARG2 | ARGI2_HUMAN | Arginase II | Kidney-type arginase | Non-hepatic arginase | Type II arginase
Type:
PROTEIN
Mol. Mass.:
38576.93
Organism:
Homo sapiens (Human)
Description:
ChEMBL_978892
Residue:
354
Sequence:
MSLRGSLSRLLQTRVHSILKKSVHSVAVIGAPFSQGQKRKGVEHGPAAIREAGLMKRLSSLGCHLKDFGDLSFTPVPKDDLYNNLIVNPRSVGLANQELAEVVSRAVSDGYSCVTLGGDHSLAIGTISGHARHCPDLCVVWVDAHADINTPLTTSSGNLHGQPVSFLLRELQDKVPQLPGFSWIKPCISSASIVYIGLRDVDPPEHFILKNYDIQYFSMRDIDRLGIQKVMERTFDLLIGKRQRPIHLSFDIDAFDPTLAPATGTPVVGGLTYREGMYIAEEIHNTGLLSALDLVEVNPQLATSEEEAKTTANLAVDVIASSFGQTREGGHIVYDQLPTPSSPDESENQARVRI
Inhibitor
Name:
BDBM290404
Synonyms:
(3R,4S)-3-amino-1-(2-(benzylamino)ethyl)-4-(3- boronopropyl)pyrrolidine-3-carboxylic acid | US10098902, Example 40 | US10603330, Example 40 | US11389464, Example 40
Type:
Small organic molecule
Emp. Form.:
C17H28BN3O4
Mol. Mass.:
349.233
SMILES:
N[C@]1(CN(CCNCc2ccccc2)C[C@@H]1CCCB(O)O)C(O)=O |r|