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Target
Retina-specific copper amine oxidase
Ligand
BDBM576552
Substrate
n/a
Meas. Tech.
SSAO Activity Assay
IC50
<20±n/a nM
Citation
 Ren, Z; Sun, X; Xu, Q SSAO inhibitors and use thereof US Patent  US11472769 Publication Date 10/18/2022
Target
Name:
Retina-specific copper amine oxidase
Synonyms:
AOC2 | AOC2_HUMAN | Retina-specific amine oxidase, copper containing
Type:
PROTEIN
Mol. Mass.:
83681.38
Organism:
Homo sapiens (Human)
Description:
ChEMBL_157252
Residue:
756
Sequence:
MHLKIVLAFLALSLITIFALAYVLLTSPGGSSQPPHCPSVSHRAQPWPHPGQSQLFADLSREELTAVMRFLTQRLGPGLVDAAQAQPSDNCIFSVELQLPPKAAALAHLDRGSPPPAREALAIVLFGGQPQPNVSELVVGPLPHPSYMRDVTVERHGGPLPYHRRPVLRAEFTQMWRHLKEVELPKAPIFLSSTFNYNGSTLAAVHATPRGLRSGDRATWMALYHNISGVGLFLHPVGLELLLDHRALDPAHWTVQQVFYLGHYYADLGQLEREFKSGRLEVVRVPLPPPNGASSLRSRNSPGPLPPLQFSPQGSQYSVQGNLVVSSLWSFTFGHGVFSGLRIFDVRFQGERIAYEVSVQECVSIYGADSPKTMLTRYLDSSFGLGRNSRGLVRGVDCPYQATMVDIHILVGKGAVQLLPGAVCVFEEAQGLPLRRHHNYLQNHFYGGLASSALVVRSVSSVGNYDYIWDFVLYPNGALEGRVHATGYINTAFLKGGEEGLLFGNRVGERVLGTVHTHAFHFKLDLDVAGLKNWVVAEDVVFKPVAAPWNPEHWLQRPQLTRQVLGKEDLTAFSLGSPLPRYLYLASNQTNAWGHQRGYRIQIHSPLGIHIPLESDMERALSWGRYQLVVTQRKEEESQSSSIYHQNDIWTPTVTFADFINNETLLGEDLVAWVTASFLHIPHAEDIPNTVTLGNRVGFLLRPYNFFDEDPSIFSPGSVYFEKGQDAGLCSINPVACLPDLAACVPDLPPFSYHGF
  
Inhibitor
Name:
BDBM576552
Synonyms:
(E)-1-(4-(((4-((2-(aminomethyl)-3- fluoroallyl)oxy)phenyl) sulfonyl)methyl)bicyclo[2.2.2]octan- 1-yl)-3-methylpyrrolidin-2-one | US11472769, Compound 83
Type:
Small organic molecule
Emp. Form.:
C24H33FN2O4S
Mol. Mass.:
464.593
SMILES:
CC1CCN(C1=O)C12CCC(CS(=O)(=O)c3ccc(OC\C(CN)=C\F)cc3)(CC1)CC2
Structure:
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