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Target
Amine oxidase [flavin-containing] B
Ligand
BDBM576546
Substrate
n/a
Meas. Tech.
SSAO Activity Assay
IC50
>30000±n/a nM
Citation
 Ren, Z; Sun, X; Xu, Q SSAO inhibitors and use thereof US Patent  US11472769 Publication Date 10/18/2022
Target
Name:
Amine oxidase [flavin-containing] B
Synonyms:
AOFB_HUMAN | MAO-B | MAOB | Monoamine oxidase type B | Monoamine oxidase type B (MAO B) | Monoamine oxidase type B (MAO B) | Monoamine oxidase type B (MAOB)
Type:
Protein
Mol. Mass.:
58768.76
Organism:
Homo sapiens (Human)
Description:
P27338
Residue:
520
Sequence:
MSNKCDVVVVGGGISGMAAAKLLHDSGLNVVVLEARDRVGGRTYTLRNQKVKYVDLGGSYVGPTQNRILRLAKELGLETYKVNEVERLIHHVKGKSYPFRGPFPPVWNPITYLDHNNFWRTMDDMGREIPSDAPWKAPLAEEWDNMTMKELLDKLCWTESAKQLATLFVNLCVTAETHEVSALWFLWYVKQCGGTTRIISTTNGGQERKFVGGSGQVSERIMDLLGDRVKLERPVIYIDQTRENVLVETLNHEMYEAKYVISAIPPTLGMKIHFNPPLPMMRNQMITRVPLGSVIKCIVYYKEPFWRKKDYCGTMIIDGEEAPVAYTLDDTKPEGNYAAIMGFILAHKARKLARLTKEERLKKLCELYAKVLGSLEALEPVHYEEKNWCEEQYSGGCYTTYFPPGILTQYGRVLRQPVDRIYFAGTETATHWSGYMEGAVEAGERAAREILHAMGKIPEDEIWQSEPESVDVPAQPITTTFLERHLPSVPGLLRLIGLTTIFSATALGFLAHKRGLLVRV
  
Inhibitor
Name:
BDBM576546
Synonyms:
(E)-N-(3-(((4-((2-(aminomethyl)-3- fluoroallyl)oxy)phenyl)sulfonyl) methyl)bicyclo[1.1.1]pentan-1- yl)pivalamide | US11472769, Compound 77
Type:
Small organic molecule
Emp. Form.:
C21H29FN2O4S
Mol. Mass.:
424.529
SMILES:
CC(C)(C)C(=O)NC12CC(CS(=O)(=O)c3ccc(OC\C(CN)=C\F)cc3)(C1)C2
Structure:
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