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Target
Protein SSX2/Protein SSXT
Ligand
BDBM565260
Substrate
n/a
Meas. Tech.
SYO1 BRD9 NanoLuc Degradation Assay
IC50
55±n/a nM
Citation
 Ruppel, SK; Yang, Z; Lowe, JT; Voigt, JH; Netherton, M Compounds and uses thereof US Patent  US11560381 Publication Date 1/24/2023
Target
Name:
Protein SSX2/Protein SSXT
Synonyms:
n/a
Type:
Protein
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
Protein SSX2
Synonyms:
CT5.2 | Cancer/testis antigen 5.2 | SSX2 | SSX2A | SSX2_HUMAN | Synovial sarcoma, X breakpoint 2 | Tumor antigen HOM-MEL-40
Type:
Protein
Mol. Mass.:
21617.50
Organism:
Human
Description:
Q16385
Residue:
188
Sequence:
MNGDDAFARRPTVGAQIPEKIQKAFDDIAKYFSKEEWEKMKASEKIFYVYMKRKYEAMTKLGFKATLPPFMCNKRAEDFQGNDLDNDPNRGNQVERPQMTFGRLQGISPKIMPKKPAEEGNDSEEVPEASGPQNDGKELCPPGKPTTSEKIHERSGPKRGEHAWTHRLRERKQLVIYEEISDPEEDDE
  
Component 2
Name:
Protein SSXT
Synonyms:
Protein SYT | SS18 | SSXT | SSXT_HUMAN | SYT | Synovial sarcoma translocated to X chromosome protein
Type:
Protein
Mol. Mass.:
45928.28
Organism:
Human
Description:
Q15532
Residue:
418
Sequence:
MSVAFAAPRQRGKGEITPAAIQKMLDDNNHLIQCIMDSQNKGKTSECSQYQQMLHTNLVYLATIADSNQNMQSLLPAPPTQNMPMGPGGMNQSGPPPPPRSHNMPSDGMVGGGPPAPHMQNQMNGQMPGPNHMPMQGPGPNQLNMTNSSMNMPSSSHGSMGGYNHSVPSSQSMPVQNQMTMSQGQPMGNYGPRPNMSMQPNQGPMMHQQPPSQQYNMPQGGGQHYQGQQPPMGMMGQVNQGNHMMGQRQIPPYRPPQQGPPQQYSGQEDYYGDQYSHGGQGPPEGMNQQYYPDGHNDYGYQQPSYPEQGYDRPYEDSSQHYYEGGNSQYGQQQDAYQGPPPQQGYPPQQQQYPGQQGYPGQQQGYGPSQGGPGPQYPNYPQGQGQQYGGYRPTQPGPPQPPQQRPYGYDQGQYGNYQQ
  
Inhibitor
Name:
BDBM565260
Synonyms:
4-(2-[1-[2-([[2,6-dimethoxy-4-(2-methyl-1-oxo-1,2-dihydro-2,7-naphthyridin-4-yl)phenyl]methyl](methyl)amino)acetyl]-[4,4-bipiperidin]-1-yl]-2-oxoethoxy)-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione | US11414416, Compound D2 | US11560381, Compound D2
Type:
Small organic molecule
Emp. Form.:
C46H51N7O10
Mol. Mass.:
861.938
SMILES:
COc1cc(cc(OC)c1CN(C)CC(=O)N1CCC(CC1)C1CCN(CC1)C(=O)COc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12)-c1cn(C)c(=O)c2cnccc12
Structure:
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