Reaction Details  Report a problem with these data
Target
Ubiquinol oxidase 1, mitochondrial
Ligand
BDBM50015089
Substrate
n/a
Meas. Tech.
Inhibitory Effects on Recombinant AOX Protein
IC50
7000±n/a nM
Citation
 Moore, AL; Albury, MS; Young, LE; Elliott, C Compounds for use as inhibitors of alternative oxidase or cytochrome bc1 complex US Patent  US11565996 Publication Date 1/31/2023
Target
Name:
Ubiquinol oxidase 1, mitochondrial
Synonyms:
AOX1 | AOX1_SAUVE | Alternative oxidase 1
Type:
Protein
Mol. Mass.:
38937.07
Organism:
Voodoo lily
Description:
P22185
Residue:
349
Sequence:
MMSSRLVGTALCRQLSHVPVPQYLPALRPTADTASSLLHGCSAAAPAQRAGLWPPSWFSPPRHASTLSAPAQDGGKEKAAGTAGKVPPGEDGGAEKEAVVSYWAVPPSKVSKEDGSEWRWTCFRPWETYQADLSIDLHKHHVPTTILDKLALRTVKALRWPTDIFFQRRYACRAMMLETVAAVPGMVGGVLLHLKSLRRFEHSGGWIRALLEEAENERMHLMTFMEVAQPRWYERALVLAVQGVFFNAYFLGYLLSPKFAHRVVGYLEEEAIHSYTEFLKDIDSGAIQDCPAPAIALDYWRLPQGSTLRDVVTVVRADEAHHRDVNHFASDVHYQDLELKTTPAPLGYH
  
Inhibitor
Name:
BDBM50015089
Synonyms:
2,N-Dihydroxy-benzamide | CHEMBL309339 | N,2-dihydroxybenzamide | SALICYLHYDROXAMIC ACID | Salicylhydroxamic acid (SHA) | Salicylic hydroxamic acid | US11565996, Compound Salicylhydroxamic acid (SHAM)
Type:
Small organic molecule
Emp. Form.:
C7H7NO3
Mol. Mass.:
153.1354
SMILES:
ONC(=O)c1ccccc1O
Structure:
Search PDB for entries with ligand similarity: