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Target
Palmitoleoyl-protein carboxylesterase NOTUM
Ligand
BDBM600801
Substrate
n/a
Meas. Tech.
Biochemical Notum Enzymatic Activity Assay
IC50
93.5±n/a nM
Citation
 Fish, PV; Mahy, W; Willis, NJ; Woodward, H; Atkinson, BN; Bayle, ED; Sipthorp, J; Jones, EY; Zhao, Y; Vecchia, L; Ruza, RR Compounds which are inhibitors of Notum US Patent  US11634391 Publication Date 4/25/2023
Target
Name:
Palmitoleoyl-protein carboxylesterase NOTUM
Synonyms:
NOTUM | NOTUM_HUMAN | Palmitoleoyl-protein carboxylesterase NOTUM | hNOTUM
Type:
PROTEIN
Mol. Mass.:
55706.36
Organism:
Homo sapiens (Human)
Description:
ChEMBL_116492
Residue:
496
Sequence:
MGRGVRVLLLLSLLHCAGGSEGRKTWRRRGQQPPPPPRTEAAPAAGQPVESFPLDFTAVEGNMDSFMAQVKSLAQSLYPCSAQQLNEDLRLHLLLNTSVTCNDGSPAGYYLKESRGSRRWLLFLEGGWYCFNRENCDSRYDTMRRLMSSRDWPRTRTGTGILSSQPEENPYWWNANMVFIPYCSSDVWSGASSKSEKNEYAFMGALIIQEVVRELLGRGLSGAKVLLLAGSSAGGTGVLLNVDRVAEQLEKLGYPAIQVRGLADSGWFLDNKQYRHTDCVDTITCAPTEAIRRGIRYWNGVVPERCRRQFQEGEEWNCFFGYKVYPTLRCPVFVVQWLFDEAQLTVDNVHLTGQPVQEGLRLYIQNLGRELRHTLKDVPASFAPACLSHEIIIRSHWTDVQVKGTSLPRALHCWDRSLHDSHKASKTPLKGCPVHLVDSCPWPHCNPSCPTVRDQFTGQEMNVAQFLMHMGFDMQTVAQPQGLEPSELLGMLSNGS
  
Inhibitor
Name:
BDBM600801
Synonyms:
(1-(4-chloro-3-(trifluoromethyl)phenyl)-1H-1,2,3-triazol-4-yl)methanol | US11634391, Compound 9
Type:
Small organic molecule
Emp. Form.:
C10H7ClF3N3O
Mol. Mass.:
277.63
SMILES:
OCc1cn(nn1)-c1ccc(Cl)c(c1)C(F)(F)F
Structure:
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