Reaction Details  Report a problem with these data
Target
Cyclin-dependent kinase 5 activator 1
Ligand
BDBM601934
Substrate
n/a
Meas. Tech.
CDK Inhibition In Vitro Assay
IC50
1.40±n/a nM
Citation
 Strum, JC Substituted 1′,2′-dihydro-3′H-spiro[cyclohexane-1,4′-pyrimido[5′,4′:4,5]pyrrolo[2,1-c][1,2,4]triazin]-3′-ones as cyclin-dependent kinase inhibitors US Patent  US11643416 Publication Date 5/9/2023
Target
Name:
Cyclin-dependent kinase 5 activator 1
Synonyms:
CD5R1_HUMAN | CDK5R | CDK5R1 | Cyclin-Dependent Kinase 5 Activator 1, p35 | Cyclin-dependent kinase 5 (CDK5/p25) | Cyclin-dependent kinase 5 regulatory subunit 1 | NCK5A | TPKII regulatory subunit | p35
Type:
Enzyme Subunit
Mol. Mass.:
34077.43
Organism:
Homo sapiens (Human)
Description:
Q15078
Residue:
307
Sequence:
MGTVLSLSPSYRKATLFEDGAATVGHYTAVQNSKNAKDKNLKRHSIISVLPWKRIVAVSAKKKNSKKVQPNSSYQNNITHLNNENLKKSLSCANLSTFAQPPPAQPPAPPASQLSGSQTGGSSSVKKAPHPAVTSAGTPKRVIVQASTSELLRCLGEFLCRRCYRLKHLSPTDPVLWLRSVDRSLLLQGWQDQGFITPANVVFLYMLCRDVISSEVGSDHELQAVLLTCLYLSYSYMGNEISYPLKPFLVESCKEAFWDRCLSVINLMSSKMLQINADPHYFTQVFSDLKNESGQEDKKRLLLGLDR
  
Inhibitor
Name:
BDBM601934
Synonyms:
4-((7'-oxo-7',8'-dihydro-6'H- spiro[cyclohexane-1,9'-pyrrolo[1,5-a:2,3- d']dipyrimidin]-2'- yl)amino)benzenesulfonamide | US11643416, Compound 2
Type:
Small organic molecule
Emp. Form.:
C20H22N6O3S
Mol. Mass.:
426.492
SMILES:
NS(=O)(=O)c1ccc(Nc2ncc3cc4NC(=O)CC5(CCCCC5)n4c3n2)cc1
Structure:
Search PDB for entries with ligand similarity: