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Target
Bcl-2-like protein 1
Ligand
BDBM608413
Substrate
n/a
Meas. Tech.
BCL-XL TR-FRET Assay
IC50
<2000±n/a nM
Citation
 Kysil, V; Parchinsky, VZ; Pushechnikov, A; Ivachtchenko, AV; Abagyan, R; Orry, A; Lam, PC; Savchuk, N Compounds having tetrahydroindolizine-1-carboxamide as BCL-2 inhibitors US Patent  US11697650 Publication Date 7/11/2023
Target
Name:
Bcl-2-like protein 1
Synonyms:
Anti-apoptotic Bcl-2 protein | Apoptosis Regulator Bcl-xL | Apoptosis regulator Bcl-X | B2CL1_HUMAN | BCL2-like 1 isoform 1 | BCL2L | BCL2L1 | BCLX | Bcl-2-like protein 1 (Bcl-XL) | Bcl-X | Bcl-xL/Bcl-2-binding component 3 | Bcl2-L-1 | Bcl2-antagonist of cell death (BAD)
Type:
Mitochondrion membrane; Single-pass membrane protein
Mol. Mass.:
26039.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
233
Sequence:
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLADSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
  
Inhibitor
Name:
BDBM608413
Synonyms:
N-(2-fluorobenzyl)-N-(4-hydroxyphenyl)-3-(6-{[(3S)-3-(morpholin-4-ylmethyl)-3,4-dihydroisoquinolin-2(1H)-yl]carbonyl}-1,3-benzodioxol-5-yl)-5,6,7,8-tetrahydroindolizine-1-carboxamide | US11697650, Compound 11 | US11697650, Example 5
Type:
Small organic molecule
Emp. Form.:
C44H43FN4O6
Mol. Mass.:
742.8338
SMILES:
Oc1ccc(cc1)N(Cc1ccccc1F)C(=O)c1cc(-c2cc3OCOc3cc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n2CCCCc12 |r|
Structure:
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