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Target
Induced myeloid leukemia cell differentiation protein Mcl-1
Ligand
BDBM608725
Substrate
n/a
Meas. Tech.
MCL-1 TR-FRET Assay
IC50
>100000±n/a nM
Citation
 Kysil, V; Parchinsky, VZ; Pushechnikov, A; Ivachtchenko, AV; Abagyan, R; Orry, A; Lam, PC; Savchuk, N Compounds having tetrahydroindolizine-1-carboxamide as BCL-2 inhibitors US Patent  US11697650 Publication Date 7/11/2023
Target
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1
Synonyms:
BCL2L3 | Bcl-2-like protein 3 | Bcl-2-like protein 3 (Mcl-1) | Bcl-2-related protein EAT/mcl1 | Bcl2-L-3 | Induced myeloid leukemia cell differentiation protein (Mcl-1) | MCL1 | MCL1_HUMAN | Mcl-1 | Myeloid Cell factor-1 (Mcl-1) | Myeloid cell leukemia sequence 1 (BCL2-related) | mcl1/EAT
Type:
Membrane; Single-pass membrane protein
Mol. Mass.:
37332.87
Organism:
Homo sapiens (Human)
Description:
Q07820
Residue:
350
Sequence:
MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGSAGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIMSPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
  
Inhibitor
Name:
BDBM608725
Synonyms:
US11697650, Compound 8 | US11697650, Example 37
Type:
Small organic molecule
Emp. Form.:
C49H54N6O7
Mol. Mass.:
838.9891
SMILES:
CN(C)CCNC(=O)c1ccc(CN(C(=O)c2cc(-c3cc4OCOc4cc3C(=O)N3Cc4ccccc4C[C@H]3CN3CCOCC3)n3CCCCc23)c2ccc(O)cc2)cc1 |r|
Structure:
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