Reaction Details  Report a problem with these data
Target
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Ligand
BDBM613061
Substrate
n/a
Meas. Tech.
Apoptosis Inhibition Assay
EC50
5.50±n/a nM
Citation
 Zhang, Z; Wang, X; Huang, S; Jiang, X; Li, L; Zhang, Z; Han, J Apoptosis inhibitors US Patent  US11725000 Publication Date 8/15/2023
Target
Name:
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Synonyms:
1.3.5.1 | Iron-sulfur subunit of complex II | SDH | SDH1 | SDHB | SDHB_HUMAN | Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Type:
PROTEIN
Mol. Mass.:
31643.02
Organism:
Homo sapiens (Human)
Description:
ChEMBL_117429
Residue:
280
Sequence:
MAAVVALSLRRRLPATTLGGACLQASRGAQTAAATAPRIKKFAIYRWDPDKAGDKPHMQTYEVDLNKCGPMVLDALIKIKNEVDSTLTFRRSCREGICGSCAMNINGGNTLACTRRIDTNLNKVSKIYPLPHMYVIKDLVPDLSNFYAQYKSIEPYLKKKDESQEGKQQYLQSIEEREKLDGLYECILCACCSTSCPSYWWNGDKYLGPAVLMQAYRWMIDSRDDFTEERLAKLQDPFSLYRCHTIMNCTRTCPKGLNPGKAIAEIKKMMATYKEKKASV
  
Inhibitor
Name:
BDBM613061
Synonyms:
US11725000, Compound 324
Type:
Small organic molecule
Emp. Form.:
C20H20FN3O5S
Mol. Mass.:
433.453
SMILES:
COc1ccc(Cn2cc(cc(F)c2=O)-c2cc(C)nc(n2)S(C)(=O)=O)cc1OC
Structure:
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