Reaction Details  Report a problem with these data
Target
Casein kinase II subunit alpha
Ligand
BDBM616482
Substrate
n/a
Meas. Tech.
Radiometric Kinase Assay
IC50
11.0±n/a nM
Citation
 Bancet, A; Cochet, C; Filhol-Cochet, O; Krimm, I; Lomberget, T; Le Borgne, M INDOLE DERIVATIVES AND USES THEREOF FOR TREATING A CANCER US Patent  US20230278983 Publication Date 9/7/2023
Target
Name:
Casein kinase II subunit alpha
Synonyms:
CK II | CK2 | CK2- alpha | CK2A1 | CSK21_HUMAN | CSNK2A1 | Casein kinase 2 | Casein kinase II (CK2) | Casein kinase II alpha/beta | Casein kinase II subunit alpha (CK2 alpha) | Casein kinase II subunit alpha (CK2A1) | Casein kinase II subunit alpha (CK2a I174A) | Casein kinase II subunit alpha (CK2a V66A) | Casein kinase II subunit alpha (CK2a dm V66I174AA) | Casein kinase II subunit alpha (CK2a)
Type:
Enzyme
Mol. Mass.:
45151.12
Organism:
Homo sapiens (Human)
Description:
P68400
Residue:
391
Sequence:
MSGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVPTPSPLGPLAGSPVIAAANPLGMPVPAAAGAQQ
  
Inhibitor
Name:
BDBM616482
Synonyms:
US20230278983, Code AB1454
Type:
Small organic molecule
Emp. Form.:
C34H36F2N6O5S
Mol. Mass.:
678.749
SMILES:
COc1cccc(CO)c1-c1ccc(cc1F)S(=O)(=O)NCCN1CCC(Cn2cc(nn2)-c2c([nH]c3ccc(F)cc23)C(C)=O)CC1 |(-8.41,5.78,;-7.01,6.41,;-6.85,7.94,;-8.09,8.85,;-7.93,10.38,;-6.52,11,;-5.28,10.1,;-3.87,10.72,;-2.62,9.82,;-5.44,8.57,;-4.19,7.66,;-2.79,8.29,;-1.54,7.38,;-1.7,5.85,;-3.11,5.22,;-4.35,6.13,;-5.76,5.5,;-.46,4.95,;.45,6.19,;-1.36,3.7,;.79,4.04,;.63,2.51,;1.88,1.6,;1.71,.07,;.31,-.55,;.15,-2.09,;1.39,-2.99,;1.23,-4.52,;2.48,-5.43,;2.48,-6.97,;3.94,-7.44,;4.85,-6.2,;3.94,-4.95,;4.42,-8.91,;3.51,-10.15,;4.42,-11.4,;5.88,-10.92,;7.22,-11.69,;8.55,-10.92,;8.55,-9.38,;9.88,-8.61,;7.22,-8.61,;5.88,-9.38,;1.97,-10.15,;1.2,-8.82,;1.2,-11.49,;2.8,-2.36,;2.96,-.83,)|
Structure:
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