Reaction Details  Report a problem with these data
Target
Rho-associated protein kinase 2 [1-119]
Ligand
BDBM561176
Substrate
n/a
Meas. Tech.
ROCK2 Kinase Activity Assay
IC50
24.0±n/a nM
Citation
 CHENG, CL; ZHAO, Y; WANG, H; ZHONG, W; LI, J; ZHAO, J; LIU, W METHOD FOR TREATING GRAFT VERSUS HOST DISEASE CAUSED BY HEMATOPOIETIC STEM CELL TRANSPLANTATION US Patent  US20230285393 Publication Date 9/14/2023
Target
Name:
Rho-associated protein kinase 2 [1-119]
Synonyms:
KIAA0619 | ROCK2 | ROCK2 (aa 1-119) | ROCK2_HUMAN | Rho-associated protein kinase 2 (ROCK2)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
13160.63
Organism:
Homo sapiens (Human)
Description:
O75116[1-119]
Residue:
119
Sequence:
MSRPPPTGKMPGAPETAPGDGAGASRQRKLEALIRDPRSPINVESLLDGLNSLVLDLDFPALRKNKNIDNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYA
  
Inhibitor
Name:
BDBM561176
Synonyms:
(6-(4-((4-(1H- pyrazol-4- yl)phenyl)amino)-5- fluoropyrimidin-2- yl)-1H-indol-2- yl)(3, 3- difluoroazetidin-1- yl)methanone | US11390609, Compound TDI01582 | US20230285393, Compound 008
Type:
Small organic molecule
Emp. Form.:
C25H18F3N7O
Mol. Mass.:
489.4519
SMILES:
Fc1cnc(nc1Nc1ccc(cc1)-c1cn[nH]c1)-c1ccc2cc([nH]c2c1)C(=O)N1CC(F)(F)C1
Structure:
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