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Target
Lysine-specific histone demethylase 1A
Ligand
BDBM645363
Substrate
n/a
Meas. Tech.
LSD1 in vitro activity assay
IC50
62.9±0.11 nM
Citation
 Liu, H; Li, J; Zhu, W; Zhou, Y; Wang, J; Su, M; Wang, S; Xu, W; Li, C; Kan, W; Jiang, H; Chen, K Trans-indoline cyclopropylamine chemical compound, and method for preparation, pharmaceutical composition, and use thereof US Patent  US11873292 Publication Date 1/16/2024
Target
Name:
Lysine-specific histone demethylase 1A
Synonyms:
AOF2 | BRAF35-HDAC complex protein BHC110 | Flavin-containing amine oxidase domain-containing protein 2 | KDM1 | KDM1A | KDM1A_HUMAN | KIAA0601 | LSD1 | Lysine-specific demethylase 1 (LSD1) | Lysine-specific histone demethylase 1 | Lysine-specific histone demethylase 1 (LSD1)
Type:
Enzyme
Mol. Mass.:
92901.01
Organism:
Homo sapiens (Human)
Description:
O60341
Residue:
852
Sequence:
MLSGKKAAAAAAAAAAAATGTEAGPGTAGGSENGSEVAAQPAGLSGPAEVGPGAVGERTPRKKEPPRASPPGGLAEPPGSAGPQAGPTVVPGSATPMETGIAETPEGRRTSRRKRAKVEYREMDESLANLSEDEYYSEEERNAKAEKEKKLPPPPPQAPPEEENESEPEEPSGVEGAAFQSRLPHDRMTSQEAACFPDIISGPQQTQKVFLFIRNRTLQLWLDNPKIQLTFEATLQQLEAPYNSDTVLVHRVHSYLERHGLINFGIYKRIKPLPTKKTGKVIIIGSGVSGLAAARQLQSFGMDVTLLEARDRVGGRVATFRKGNYVADLGAMVVTGLGGNPMAVVSKQVNMELAKIKQKCPLYEANGQAVPKEKDEMVEQEFNRLLEATSYLSHQLDFNVLNNKPVSLGQALEVVIQLQEKHVKDEQIEHWKKIVKTQEELKELLNKMVNLKEKIKELHQQYKEASEVKPPRDITAEFLVKSKHRDLTALCKEYDELAETQGKLEEKLQELEANPPSDVYLSSRDRQILDWHFANLEFANATPLSTLSLKHWDQDDDFEFTGSHLTVRNGYSCVPVALAEGLDIKLNTAVRQVRYTASGCEVIAVNTRSTSQTFIYKCDAVLCTLPLGVLKQQPPAVQFVPPLPEWKTSAVQRMGFGNLNKVVLCFDRVFWDPSVNLFGHVGSTTASRGELFLFWNLYKAPILLALVAGEAAGIMENISDDVIVGRCLAILKGIFGSSAVPQPKETVVSRWRADPWARGSYSYVAAGSSGNDYDLMAQPITPGPSIPGAPQPIPRLFFAGEHTIRNYPATVHGALLSGLREAGRIADQFLGAMYTLPRQATPGVPAQQSPSM
  
Inhibitor
Name:
BDBM645363
Synonyms:
US11873292, Compound A19 | trans-N1-(2-(1-(phenylsulfonyl) indolin-5-yl)cyclopropyl) cyclohexane-1,4-diamine
Type:
Small organic molecule
Emp. Form.:
C23H29N3O2S
Mol. Mass.:
411.56
SMILES:
NC1CCC(CC1)NC1CC1c1ccc2N(CCc2c1)S(=O)(=O)c1ccccc1 |(9.26,2.27,;7.77,2.67,;6.68,1.58,;5.2,1.98,;4.8,3.47,;5.89,4.55,;7.37,4.16,;3.31,3.86,;2.22,2.78,;1.45,4.11,;.68,2.78,;-.65,2.01,;-.65,.47,;-1.99,-.3,;-3.32,.47,;-4.78,-.01,;-5.69,1.24,;-4.78,2.48,;-3.32,2.01,;-1.99,2.78,;-5.26,-1.47,;-3.72,-1.47,;-4.49,-2.81,;-6.59,-2.24,;-7.93,-1.47,;-9.26,-2.24,;-9.26,-3.78,;-7.93,-4.55,;-6.59,-3.78,)|
Structure:
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