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Serine/threonine-protein kinase SIK1
Ligand
BDBM647334
Substrate
n/a
Meas. Tech.
In Vitro SIK2 Kinase Assay
IC50
233±n/a nM
Citation
Wein, MN; Greenlee, WJ SALT INDUCIBLE KINASE INHIBITORS US Patent US20240025892 Publication Date 1/25/2024More Info.:
Target
Name:
Serine/threonine-protein kinase SIK1
Synonyms:
SIK | SIK1 | SIK1_HUMAN | SNF1LK
Type:
PROTEIN
Mol. Mass.:
84908.20
Organism:
Homo sapiens (Human)
Description:
ChEMBL_774213
Residue:
783
Sequence:
MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ
Inhibitor
Name:
BDBM647334
Synonyms:
US20240025892, Example 41
Type:
Small organic molecule
Emp. Form.:
C22H18N4O
Mol. Mass.:
354.4045
SMILES:
Cc1ccc(CCOc2ccn3c(cnc3c2)-c2ccc(cc2)C#N)cn1
Structure:
