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Target
Sepiapterin reductase
Ligand
BDBM659784
Substrate
n/a
Meas. Tech.
Measurement of Human SPR Inhibitory Activity Assay
IC50
0.640±n/a nM
Citation
 KAMAURA, M; INABA, Y; SHINTANI, Y; KUWANO, Y; NAKAO, M; NAGAI, H; KUROSE, N; TAKAYA, K; NAKAJIMA, M CONDENSED HETEROCYCLIC COMPOUND US Patent  US20240092784 Publication Date 3/21/2024
Target
Name:
Sepiapterin reductase
Synonyms:
SPR | SPRE_HUMAN | Sepiapterin reductase (SPR)
Type:
Enzyme
Mol. Mass.:
28050.66
Organism:
Homo sapiens (Human)
Description:
P35270
Residue:
261
Sequence:
MEGGLGRAVCLLTGASRGFGRTLAPLLASLLSPGSVLVLSARNDEALRQLEAELGAERSGLRVVRVPADLGAEAGLQQLLGALRELPRPKGLQRLLLINNAGSLGDVSKGFVDLSDSTQVNNYWALNLTSMLCLTSSVLKAFPDSPGLNRTVVNISSLCALQPFKGWALYCAGKAARDMLFQVLALEEPNVRVLNYAPGPLDTDMQQLARETSVDPDMRKGLQELKAKGKLVDCKVSAQKLLSLLEKDEFKSGAHVDFYDK
  
Inhibitor
Name:
BDBM659784
Synonyms:
N6-Cyclopropyl-7-hydroxy-4-isobutyl-5-oxo-N3-((tetrahydro-2H-pyran-4-yl)methyl)-4,5-dihydropyrazolo[1,5-a]pyrimidine-3,6-dicarboxamide | US20240092784, Example 221
Type:
Small organic molecule
Emp. Form.:
C21H29N5O5
Mol. Mass.:
431.4855
SMILES:
CC(C)Cn1c2c(cnn2c(O)c(C(=O)NC2CC2)c1=O)C(=O)NCC1CCOCC1
Structure:
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