Reaction Details  Report a problem with these data
Target
Mitogen-activated protein kinase 14
Ligand
BDBM15414
Substrate
biotinylated GST-ATF2
Meas. Tech.
Enzyme Inhibition Assay
pH
7.2±n/a
Temperature
303.15±n/a K
IC50
5±0.5 nM
Citation
 McClure, KF; Abramov, YA; Laird, ER; Barberia, JT; Cai, W; Carty, TJ; Cortina, SR; Danley, DE; Dipesa, AJ; Donahue, KM; Dombroski, MA; Elliott, NC; Gabel, CA; Han, S; Hynes, TR; Lemotte, PK; Mansour, MN; Marr, ES; Letavic, MA; Pandit, J; Ripin, DB; Sweeney, FJ; Tan, D; Tao, Y Theoretical and experimental design of atypical kinase inhibitors: application to p38 MAP kinase. J Med Chem 48:5728-37 (2005) [PubMed]  Article
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM15414
Synonyms:
4-(4-fluorophenyl)-5-[3-(propan-2-yl)-[1,2,4]triazolo[3,4-a]pyridin-6-yl]-1,3-oxazole | 6-[4-(4-Fluoro-phenyl)-oxazol-5-yl]-3-isopropyl-[1,2,4]-triazolo[4,3-a]pyridine | CP-808844 | Triazolopyridine deriv. 25
Type:
Small organic molecule
Emp. Form.:
C18H15FN4O
Mol. Mass.:
322.3363
SMILES:
CC(C)c1nnc2ccc(cn12)-c1ocnc1-c1ccc(F)cc1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
biotinylated GST-ATF2
Synonyms:
ATF-2-GST | ATF2 | Activating transcription factor 2 | Activating transcription factor 2-GST fusion | GST-ATF2 | biotinylated ATF2 substrate | biotinylated activating transcription factor 2
Type:
Other Protein Type
Mol. Mass.:
12237.77
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
109
Sequence:
MSDDKPFLCTAPGCGQRFTNEDHLAVHKHKHEMTLKFGPARNDSVIVADQTPTPTRFLKNCEEVGLFNELASPFENEFKKASEDDIKKMPLDLSPLATPIIRSKIEEPS